- Original Article
- Effects of Cisapride on Action Potential Duration and on ATP-Sensitive K Channel in Guinea Pig Ventricular Muscles
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Chan Uhng Joo, Young Jae Kim, Sung Ki Mun, Soo Wan Chae
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Clin Exp Pediatr. 1999;42(7):953-958. Published online July 15, 1999
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Purpose : Cisapride(PrepulsidⓇ) has been recently associated with long QT syndrome. It has been reported to cause Torsades de Pointes and induce early afterdepolarization in rabbit Purkinje fibers. We investigated the electrophysiological effects of cisapride on cardiac action potential duration and ATP-sensitive K channel in papillary muscles.
Methods : Cardiac action potentials in guinea pig papillary muscle were recorded with microelectrodes... |
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- Effects of Adriamycin on Membrane Potential and Intracellular Sodium Activity in Canine Purkinje fibers
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Chan Uhng Joo, Soo Wan Chae
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Clin Exp Pediatr. 1992;35(8):1107-1112. Published online August 15, 1992
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Anthracycline antibiotic adriamycin (doxorubicin) is presently considered to be a very effective chemotherapeutic agent in the treatment of many human tumors. Adriamycin induced cardiomyopathy limits its clincal use. A number of hypotheses have been proposed to explain the mechanism of cardiotoxicity with adriamycin, but none has yet been demonstrated. The effects of adriamycin on membrane potential and intracellular sodium ion... |
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- The effects of adriamycin on twitch force and membrane potential in an isolated Guinea-pig papillary muscle.
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Chan Uhng Joo, Pyung Han Hwang, Jung Soo Kim, Hee Cheol Yu, Soo Wan Chae
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Clin Exp Pediatr. 1991;34(5):677-681. Published online May 31, 1991
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The antiumor antibiotic adriamycin is presently considered to be a very effctive and useful
chemotherapeutic agent in the treatment of many human tumors. Cardiotoxicity of adriamycin limits
its clinical use. A number of hypotheses have been proposed to explain the mechanism of cardiotox-
icity with adriamycin, but none has yet been demonstrated.
The effects of adriamycin on twitch force and membrane potential in an... |
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